Wayne, born Dwayne Michael Carter Jr., could spend up to 10 years behind bars if convicted on the new charge, which stems from a December 2019 incident where federal agents searched his plane.
Officials allegedly found a gold-plated .45 caliber handgun, along with ecstasy, heroin and marijuana, inside a handbag on the plane.
He is due in court next month.
Lil Wayne could face prison time over gun charge
The 38 years old US rapper was charged with one count of possession of a firearm and ammunition by a convicted felon
He was previously convicted of a felony gun charge in 2009 and served a year behind bars for the crime.